Virulence of Rimantadine-Resistant Human Influenza A (H3N2) Viruses in Ferrets
Identifieur interne : 002001 ( Main/Exploration ); précédent : 002000; suivant : 002002Virulence of Rimantadine-Resistant Human Influenza A (H3N2) Viruses in Ferrets
Auteurs : Clive Sweet [États-Unis] ; Frederick G. Hayden [États-Unis] ; Kenneth J. Jakeman [États-Unis] ; Setareh Grambas [États-Unis] ; Alan J. Hay [États-Unis, Royaume-Uni]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1991.
Abstract
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.
Url:
DOI: 10.1093/infdis/164.5.969
Affiliations:
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Hayden</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Microbial Molecular Genetics and Cell Biology Research Group, School of Biological Sciences, University of Birmingham, and Virology Division, National Institute for Medical Research, London, United Kingdom, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Jakeman, Kenneth J" sort="Jakeman, Kenneth J" uniqKey="Jakeman K" first="Kenneth J." last="Jakeman">Kenneth J. 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Hay</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Microbial Molecular Genetics and Cell Biology Research Group, School of Biological Sciences, University of Birmingham, and Virology Division, National Institute for Medical Research, London, United Kingdom, Charlottesville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reprints or correspondence: Dr. Alan J. Hay. Virology Division, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 IAA</wicri:regionArea><wicri:noRegion>NW7 IAA</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1991-11">1991</date><biblScope unit="vol">164</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="969">969</biblScope><biblScope unit="page" to="972">972</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. 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Hayden</name><name sortKey="Jakeman, Kenneth J" sort="Jakeman, Kenneth J" uniqKey="Jakeman K" first="Kenneth J." last="Jakeman">Kenneth J. Jakeman</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Hay, Alan J" sort="Hay, Alan J" uniqKey="Hay A" first="Alan J." last="Hay">Alan J. Hay</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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